The overall aims of the research program are to develop and apply NMR spectroscopy for studies of chemically and biologically interesting problems. Towards this end it is helpful to utilize a wide range of approaches, including those associated with both high resolution solid-state NMR spectroscopy and multidimensional solution NMR spectroscopy. Particularly, the study of partially ordered systems is an interesting area wherein several approaches applicable to solution and solid state NMR spectroscopy can be tested. The study of oriented systems has also implications for a number of scientifically and technologically important materials. The fact that lipids and model membranes show liquid crystalline behavior has influenced our studies of oriented samples spinning at and away from Magic Angle. The systematic study has revealed the dynamics of the director under such conditions as well as has made possible the sign of the order parameter to be determined when different interactions are present. It was shown that the orientation of the chemical shift tensor, which is related to the molecular structure, could also be determined. For the first time, the intensity oscillations observed during cross polarisation have been used to obtain dipolar couplings and order parameters in the case of a liquid crystal. A two-dimensional experiment with a modified pulse scheme has also been shown to be quite useful for this purpose . Further improvements to the method, with the removal of homonuclear dipolar couplings, have recently become possible for routine use. A novel application of the NMR spectra of liquid crystals in quantum computing is also being tested.